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E45 Lotion has been clinically proven to treat and soothe dry, itching, flaking, chapped, rough and calloused skin, sunburn and detergent hands. Its non-greasy emollient formulation is quickly absorbed by your skin , leaving it soft, comfortable and relieved. E45 is recommended for more serious dry skin conditions such as eczema, dermatitis, ichthyosis and certain dry cases of psoriasis.